KMID : 1123920140280030330
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Korean Journal of Oriental Physiology and Pathology 2014 Volume.28 No. 3 p.330 ~ p.336
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Anti-inflammatory Effect of Combination of Scutellariae Radix and Lonicerae Caulis Water Extract
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Hsia Yu-Chun
Choi You-Kyung
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Abstract
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This study aimed at examining the anti-inflammatory effects of Scutellariae Radix & Lonicerae Caulis water extract(SC). RAW 264.7 mouse macrophage cells were treated with 25¡200§¶/§¢ SC for 24 hours. Cell viability was then measured using MTT assays. The nitric oxide(NO) production and the creation of several cytokines in LPS-stimulated RAW 264.7 cells were investigated. SC inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50 and 200 §¶/§¢. SC inhibited significantly the TNF-¥á of the RAW 264.7 cell induced by LPS at the density of 50§¶/§¢. SC inhibited significantly the MIP-1¥á of the RAW 264.7 cell induced by LPS at the density of 25, 50 and 100§¶/§¢. SC inhibited significantly the MIP-1¥â, MIP-2 at the density of 50, 100§¶/§¢ in the RAW 264.7 cell increased by LPS, respectively. SC did not affect the production levels of VEGF in RAW 264.7 cell. As a result, SC significantly inhibited the inductions of MIP-1¥á, MIP-1¥â, MIP-2 and NO in LPS-induced RAW 264.7 cell without causing the toxicity. These results signify that SC has anti-inflammatory effects on controlling the over inflammatory reaction on the RAW 264.7 cell.
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KEYWORD
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Scutellariae Radix, Lonicerae Caulis, anti-inflammation, NO, TNF-¥á, MIP-1¥á, MIP-1¥â, MIP-2
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